Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HRH1 was differentially expressed in adults with asthma vs. controls (p = 0.04), and EDN1 was differentially expressed in children with asthma vs. controls 12-18 years old (p = 0.03).
|
23448392 |
2013 |
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
MZC is the effective part of MZ and the anti-asthmatic mechanisms ware related to its significant reduction in contents of ET-1, NO, EOS and the damage of lung tissue possibly.
|
16981460 |
2006 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increase in interleukin 13 and endothelin-1 in serum and bronchoalveolar lavage fluid in OVA-induced asthmatic mice are also decreased by ICA.
|
31744482 |
2019 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested a hypothesis that asthma or other atopic diseases are associated with insertion/deletion ACE, M235T angiotensinogen, and TaqI ET-1 gene polymorphisms.
|
10200023 |
1999 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Plasma endothelin-1 immunoreactivity in asthmatic children.
|
11991554 |
2002 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Literature results on the genetic association of EDN1 in asthma are inconsistent.
|
17960156 |
2008 |
Asthma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Targeting EDN1 might represent a novel therapeutic strategy for severe steroid-refractory asthma.
|
17996929 |
2007 |
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, erythromycin and clarithromycin inhibited ET-1 expression in bronchoepithelial cells from patients with chronic, stable asthma.
|
9701415 |
1998 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Literature results on the genetic association of EDN1 in asthma are inconsistent.
|
17960156 |
2008 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma.
|
17470272 |
2007 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These are the IL10 -592C>A SNP in the interleukin 10 gene (p=0.036 for eosinophil cell counts), the 4124T>C SNP in EDN1 (p=0.044 for asthma), the 3391C>T SNP in NOS1 with eosinophil cell counts (p=0.0086), and the 5266C>T polymorphism, also in the NOS1 gene, for high IgE levels (p=0.022).
|
11668616 |
2001 |
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings are consistent with the hypothesis that elevated endothelin-1 levels contribute to subepithelial thickening and highlight this factor as a possible therapeutic target for difficult-to-treat fungal-induced asthma.
|
30737857 |
2019 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeting EDN1 might represent a novel therapeutic strategy for severe steroid-refractory asthma.
|
17996929 |
2007 |